The Swiss National Center of Competence in Research (NCCR) Structural Biology is a research consortium specializing in the structural biology of membrane proteins and supramolecular complexes. It is funded by the Swiss Science Foundation (SNF), the University of Zürich (UZH), and the ETH Zürich (ETH). Its network includes 14 research groups at the UZH, ETH, the Paul Scherrer Institute (PSI), the Swiss Light Source (SLS),
and the Biozentrum of the University of Basel. 

High resolution structure of a heterodimeric ABC transporter

26.03.2012. NCCR Scientists have solved the first crystal structure of a heterodimeric ABC transporter to a resolution of 2.9 Å.

Korkhov VM, Mireku SA, Hvorup RN, Locher KP. (2012) Asymmetric states of vitamin B12 transporter BtuCD are not discriminated by its cognate substrate binding protein BtuF. FEBS Lett. Apr 5;586(7):972-6. Epub Mar 8. PubMed

Parizek P, Kummer L, Rube P, Prinz A, Herberg FW, Plückthun A. (2012) Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-specific Intracellular Inhibitors of c-Jun N-terminal Kinases. ACS Chem Biol.May 8. [Epub ahead of print] PubMed

A novel crystallization plate

The group of Markus Grütter at the University of Zurich developed a novel capillary crystallization plate - the CrystalHarp. Users of the NCCR Crystallization Facility interested in testing this plate may contact Beat Blattmann (email) or Mareike Kurz (email) for further information.